And it’s not the only study indicating that synergy between NAD+ and CoQ10, in supplement form, packs a powerful punch in combating fatigue and chronic disease.
William Vickers, MD, states, “As a downstream component in the Krebs cycle involved with mitochondrial ATP production, numerous investigators have been looking into NAD+ and CoQ10 for chronic fatigue/ME, neurologic disorders, and pathogens that cause brain fog.”
A 2007 study supports these claims, citing NAD+ and CoQ10 as a powerful combination for the support in preventing ischemic brain damage. Another study looking at Parkinson’s disease showed that a synergistic effect exists between NAD+ and CoQ10 and that the combined supplementation could mitigate the clinical symptoms associated with this debilitating disease.
A more recent 2018 study explored NAD+ supplementation alone in relation to Alzheimer’s Disease. In Alzheimer’s Disease patients, DNA repair activation is significantly impaired leading to the formation of brain plaques which are the end stage clinical manifestation of the disease. In this study, researchers found NAD+ supplementation normalized neuroinflammation, improved synaptic transmission, and decreased DNA damage. In addition, their results showed improved learning, memory, and motor function.
A separate and older study conducted in 1998 showed the beneficial effects of CoQ10 supplementation alone for improving markers of neurodegeneration. In this study done on rat populations, CoQ10 supplementation was shown to increase brain cell mitochondria concentrations and clinical markers for neurodegeneration. Researchers concluded that CoQ10 could prove a viable compound in preventing and reducing symptoms of neurodegenerative disorders.
The Defined Science Unveiled
But, how exactly do NAD+ and CoQ10 impact the mitochondria? How can we explain these studies based on what the science community considers fact?
CoQ10, also known as Coenzyme Q10, is a powerful antioxidant. It is a well-known free radical scavenger for mitochondrial and lipid membranes. In other words, it protects and supports proper mitochondrial health. In addition to its antioxidant properties, it is directly involved in the electron transport chain reaction that leads to the production of ATP.
NAD+ also plays a critical role in the electron transport chain. NAD+ functions as the primary electron donor in the reaction, also known as oxidative phosphorylation, and is the main initiator of that reaction. The outcome of oxidative phosphorylation is the production of the molecule ATP. This process is severely disturbed in mitochondrial-associated disorders – like Parkinson’s Disease, Alzheimer’s Disease, and chronic fatigue conditions. Many other health issues – such as inflammatory diseases and cancer – are directly correlated with decreased NAD+ levels.
When it comes to mitochondrial support, the combined added effects of NAD+ and CoQ10 provide a synergy that is unmatched. Together, their protective and energy producing capacities support optimal mitochondrial health in every cell of the body, especially the brain. It’s what makes Nadovim the powerful and revolutionary supplement that it is.