“Like an “On” switch for brain energy.”
* Nootropic Geek
* Nootropic Geek
01
Oxidative stress in the brain increases with age.
NAD+ depletes in direct correlation.
Research "emphasizes the pivotal role of NAD+ in the regulation of DNA repair,
stress resistance, and cell death, suggesting that NAD+ synthesis through the
kynurenine pathway and/or salvage pathway is an attractive target for therapeutic
intervention in age-associated degenerative disorders."
NAD+ depletes in direct correlation.
Research "emphasizes the pivotal role of NAD+ in the regulation of DNA repair,
stress resistance, and cell death, suggesting that NAD+ synthesis through the
kynurenine pathway and/or salvage pathway is an attractive target for therapeutic
intervention in age-associated degenerative disorders."
NAD+ metabolism and oxidative stress. Redox Rep. 2012;17(1):28-46.
NAD+
A Closer Look
“NAD+ is like the fountain of youth.”
* David Sinclair, co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.
* David Sinclair, co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.
02
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging
and are involved in age-related metabolic decline.
Scientists "demonstrated that NAD+ availability decreases over age,
reducing sirtuin activities and affecting the communication between the nucleus and
mitochondria at a cellular level...These dynamic cellular and systemic processes likely
contribute to the development of age-associated functional decline ..To mitigate these
age-associated problems, supplementation of key NAD+ intermediates is currently
drawing significant attention."
and are involved in age-related metabolic decline.
Scientists "demonstrated that NAD+ availability decreases over age,
reducing sirtuin activities and affecting the communication between the nucleus and
mitochondria at a cellular level...These dynamic cellular and systemic processes likely
contribute to the development of age-associated functional decline ..To mitigate these
age-associated problems, supplementation of key NAD+ intermediates is currently
drawing significant attention."
npj Aging and Mechanisms of Disease volume 2, Article number: 16017 (2016)
NAD+
The Aging Brain
