Science Behind Nadovim - How NAD+ Improves Brain Function

The Art and Science of Brain Supplementation.

Saying the brain is complex is an understatement.
Nevertheless, Nadovim simplifies the task of optimizing brain performance by melding science, clinical experience, and a unique research and development process.

WHAT IS NAD+?

The Essence of Life

As we grow older, certain genes can be triggered that accelerate degenerative processes. This can result in symptoms such as chronic fatigue, loss of mental clarity, depression, stress, anxiety, and various other ailments. A critical factor in this process is a coenzyme by the name of nicotinamide adenine dinucleotide (NAD+),
that enables the transfer of energy from the foods we eat to vital cell functions, especially in the brain. Every cell in the body needs it. The problem comes when NAD+ levels begin to decline, either due to lifestyle, diet, use of drugs/alcohol, stress,
toxins, or a host of other factors.

So what’s the solution? Keep reading.

“Like an “On” switch for brain energy.”
* Nootropic Geek

01 Oxidative stress in the brain increases with age.
NAD+ depletes in direct correlation.

Research "emphasizes the pivotal role of NAD+ in the regulation of DNA repair,
stress resistance, and cell death, suggesting that NAD+ synthesis through the
kynurenine pathway and/or salvage pathway is an attractive target for therapeutic
intervention in age-associated degenerative disorders."
NAD+ metabolism and oxidative stress. Redox Rep. 2012;17(1):28-46.

NAD+

A Closer Look

Graph of how NAD+ levels decline as we age and oxidative damage increases in direct relation.

“NAD+ is like the fountain of youth.”
* David Sinclair, co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.

02 Nicotinamide adenine dinucleotide (NAD) levels decrease during aging
and are involved in age-related metabolic decline.

Scientists "demonstrated that NAD+ availability decreases over age,
reducing sirtuin activities and affecting the communication between the nucleus and
mitochondria at a cellular level...These dynamic cellular and systemic processes likely
contribute to the development of age-associated functional decline ..To mitigate these
age-associated problems, supplementation of key NAD+ intermediates is currently
drawing significant attention."
npj Aging and Mechanisms of Disease volume 2, Article number: 16017 (2016)

NAD+

The Aging Brain

Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline.

THE FORMULA

A Comprehensive Nutraceutical

quantities shown per serving (2 capsules)

Research (scroll over an ingredient to learn more)

NAD+

NAD+ and NADH in brain functions, brain diseases and brain aging

“Numerous studies have suggested that NAD+ and NADH mediate multiple major biological processes, including calcium homeostasis, energy metabolism, mitochondrial functions, cell death and aging. Increasing evidence has also suggested that NAD+ and NADH play important roles in multiple biological processes in brains, such as neurotransmission and learning and memory. NAD+ and NADH may also mediate brain aging and the tissue damage in various brain illnesses. Our latest studies have suggested that NADH can be transported across the plasma membranes of astrocytes, and that NAD+ administration can markedly decrease ischemic brain injury. Based on this information, it is proposed that NAD+ and NADH are fundamental mediators of brain functions, brain senescence and multiple brain diseases.”

Bacopa

Neuropharmacological Review of the Nootropic Herb Bacopa monnieri

“Bacopa monnieri (BM) is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer. Numerous animal and in vitro studies have been conducted, with many evidencing potential medicinal properties. Several randomized, double-blind, placebo-controlled trials have substantiated BM’s nootropic utility in humans. There is also evidence for potential attenuation of dementia, Parkinson’s disease, and epilepsy.”

Cat’s Claw

Cat’s Claw shown to increase Brain-Derived Neurotrophic Factor and improve cognition & focus.

A South American vine with neuroprotective properties, this natural ingredient has been shown to increase brain-derived neurotrophic factor, fight inflammation and free radical damage, repair DNA, alleviate depression, and improve cognition and focus. Research shows that Cat’s Claw has a positive impact on the hippocampus for neurogenesis resulting in improved memory and learning. Cat’s Claw also elevates levels of Tryptophan which increases serotonin and can reduce depressive moods.

CoQ10

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

“Coenzyme Q10 is an essential cofactor of the electron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q10 increased cerebral cortex concentrations in 12- and 24-month-old rats. These results show that oral administration of coenzyme Q10 increases both brain and brain mitochondrial concentrations. They provide further evidence that coenzyme Q10 can exert neuroprotective effects that might be useful in the treatment of neurodegenerative diseases.”

Magnesium malate

Enhancement of learning and memory by elevating brain magnesium.

“Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.”

Thiamin

Thiamin deficiency and brain disorders

“Thiamin plays a key role in the maintenance of brain function. Thiamin diphosphate is cofactor for several enzymes involved in glucose metabolism whereas thiamin triphosphate has distinct properties at the neuronal membrane. Thiamin metabolism in the brain is compartmented between neurons and neighbouring glial cells. Decreased activities of thiamin diphosphate-dependent enzymes (in particular alpha-ketoglutarate dehydrogenase) have also been reported in neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases independent of patient malnutrition.”

Glycine

Glycine an important amino acid in supporting cognitive performance and the central nervous system

Glycine is an amino acid that is essential for numerous cognitive and metabolic functions. Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. Glycine is involved in the transmission of chemical signals in the brain and current research is focussed on its use for mental disorders, schizophrenia, depression, sleep problems, and improving memory.

Aspartic Acid

Aspartic Acid critical in brain and neural health.

Aspartic acid is often connected to mental acuity and keeping the mind sharp. The amino acid is reponsible for increasing concentrations of NADH in the brain and increasing the production of chemicals required for proper mental functioning. Aspartic acid also plays a role in removings toxins from cells including ammonia, which is known to cause damage to the human brain, nervous system, and liver.

NAD+

Nicotinamide adenine dinucleotide

200 mg

An incredibly important coenzyme required for producing all cellular energy, especially in the brain.

Bacopa

Bacopa Monnieri

452 mg proprietary blend

An adaptogenic herb known for its ability to improve neurotransmitter regulation, reduce stress, and improve brain function.

Cat’s Claw

Uncaria tomentosa

452 mg proprietary blend

A powerful natural anti-inflammatory that also promotes cerebral circulation and is used widely for immunity, fatigue and DNA repair.

CoQ10

Coenzyme Q10

33 mg

An antioxidant that helps mitochondrial function and energy generation.

Magnesium

Dimagnesium malate

150 mg

A mineral that helps normalize neurotransmitters and has been linked to enhanced memory.

Thiamin

Vitamin B1

70 mg

A vitamin responsible for regulating neurotransmitters and commonly used as a supportive treatment for Alzheimer’s disease.

Glycine

3 mg

Commonly referred as an “anti-aging” amino acid for its ability to protect and repair muscle tissue and joint cartilage.

Aspartic Acid

3 mg

A non-essential amino acid that aids in the absorption of essential amino acids and acts as an important building block for cells and tissue.

R&D

Purity. Potency. Compatibility.

It took a pioneer in integrative medicine, a specialized pharmaceutical
& nutraceutical development team and over two years of hard work to ensure
Nadovim was a cut above the rest.

01Inception

It starts with an idea. A mission to change not just how people think, but their ability to do so.

03Procurement

Individual sourced raw ingredients from qualified vendors are put through a rigorous certification process and tested by our medical team and via lab analysis for superior quality.

05Production

Nadovim is manufactured at a state-of-the-art manufacturing facility that is FDA-registered and inspected.

07Clinical Review

Before hitting the market, we turned to leading physicians in the US to prescribe Nadovim to their patients with real brain issues.

02Formulation

Utilizing clinical expertise and then beginning an arduous process of bioenergetic compatibility testing of specific ratios, a formula is created.

04Feasibility

Lab technicians run feasibility tests to ensure the formula, utilizing specialized ingredients and specific ratios, is stable.

06Purity / Quality Testing

Again turning to our medical team, Dr. Szulc, and lab analysis, purity specification analysis and quality testing are performed on Nadovim.

08Ongoing Lot Analysis

Each batch of raw material and lot of final product is continuously tested for purity, quality, compliance, and safety prior to being released to customers and physicians.

01Inception

It starts with an idea. A mission to change not just how people think, but their ability to do so.

02Formulation

Utilizing clinical expertise and then beginning an arduous process of bioenergetic compatibility testing of specific ratios, a formula is created.

03Procurement

Individual sourced raw ingredients are tested by our medical team and via lab analysis for superior quality.

04Feasability

Lab technicians run feasability tests to ensure the formula, utilizing specialized ingredients and specific ratios is stable.

05Production

Bioenergetic analysis to confirm quality, the

06Purity / Quality Testing

Again turning to our medical team, Dr. Szulc, and lab analysis, purity specification analysis and quality testing are performed on Nadovim.

07Clinical Testing

Before hitting the market, we turned to leading physicians in the US to prescribe Nadovim to their patients with real brain issues. See results.

08Ongoing Lot Analysis

Each batch of raw material and lot of final product is continuously tested for purity, quality, compliance, and safety prior to being released to customers and physicians.

“Take Nadovim, which contains a coenzyme called Nicotinamide adenine dinucleotide (NAD+). The ingredient keeps mitochondria healthy, which is necessary.”

Robin Foroutan, RDN
Integrative Nutritionist at The Morrison Center

NADOVIM CLINICAL EXPERIENCE

Doctor

Recommended.

William Vickers, MD

Medical Director, Mid Atlantic Integrative Center

“NAD+ and the use of Nadovim is now an integral part of treatment in neurodegenerative disorders at our clinic. After trialing it on 25 patients and seeing results within 2-3 weeks with Nadovim, we are now using it on most of our patients.”

EXPLORE MORE CLINICAL EXPERIENCE